Water For Life

• Dohi, K., et al., Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury. PLoS One, 2014. 9(9): p. e108034.

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• Kashiwagi, T., et al., Electrochemically reduced water protects neural cells from oxidative damage. Oxid Med Cell Longev, 2014. 2014: p. 869121.

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• Hong, Y., et al., Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway. PLoS One, 2014. 9(4): p. e96212.

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• Yuan, J., et al., Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway. J Surg Res, 2018. 228: p. 238-246.

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• Wu, X., et al., Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. Brain Res, 2018.

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• Wang, H., et al., Hydrogen-Rich Saline Activated Autophagy via HIF-1alpha Pathways in Neuropathic Pain Model. Biomed Res Int, 2018. 2018: p. 4670834.

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• Varga, V., et al., Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs. Acta Pharmacol Sin, 2018.

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• Satoh, Y., et al., Molecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity Blast in Mice. J Neuropathol Exp Neurol, 2018.

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• Nishimaki, K., et al., Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res, 2018. 15(5): p. 482-492.

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• Jiang, X., et al., FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia. Behav Brain Res, 2018.

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• Imai, K., et al., Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model. Sci Rep, 2018. 8(1): p. 9221.

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• Huang, J.L., W.W. Liu, and X.J. Sun, Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion independent of anti-necroptosis. Med Gas Res, 2018. 8(1): p. 1-5.

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• Hou, C., et al., Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Abeta clearance. Free Radic Res, 2018: p. 1-12.

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• Choi, K.S., et al., Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model. Brain Res Bull, 2018. 142: p. 122-128.

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• Ono, H., et al., Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. J Stroke Cerebrovasc Dis, 2017.

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• Nishimaki, K., et al., Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment. Curr Alzheimer Res, 2017.

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• Yoshii, Y., et al., Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice. Neurochem Res, 2017.

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• Yoneda, T., et al., Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet. Nutrients, 2017. 9(1).

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• Wen, D., et al., Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice. Neuropharmacology, 2017. 118: p. 199-208.

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• Shi, Y., et al., Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats. Neuroreport, 2017. 28(17): p. 1170-1175.

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• Murakami, Y., M. Ito, and I. Ohsawa, Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis. PLoS One, 2017. 12(5): p. e0176992.

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• Mizuno, K., et al., Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Med Gas Res, 2017. 7(4): p. 247-255.

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• Yoritaka, A., et al., Pilot study of H(2) therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial. Movement Disorders, 2013.

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• Matsuoka, T., et al., Hydrogen gas inhalation inhibits progression to the “irreversible” stage of shock after severe hemorrhage in rats. J Trauma Acute Care Surg, 2017.

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• Ma, H., et al., [Hydrogen-rich saline attenuates hyperalgesia and reduces cytokines in rats with post-herpetic neuralgia via activating autophagy]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2017. 33(2): p. 155-158.

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• Liu, Y., et al., Effect of hydrogen-rich water on the angiogenesis in lesion boundary brain tissue of traumatic brain injury-challenged rats. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017. 10(3): p. 3807-3815.

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• Li, D. and Y. Ai, Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogen-activated protein kinasecaspase3 signaling pathway following cerebral ischemia-reperfusion injury. Mol Med Rep, 2017. 16(4): p. 5321-5325.

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• Li, C., et al., Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels. Am J Transl Res, 2017. 9(3): p. 1162-1172.

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• He, Y., et al., Image-guided hydrogen gas delivery for protection from myocardial ischemia-reperfusion injury via microbubbles. ACS Appl Mater Interfaces, 2017.

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• Gao, Q., et al., Molecular hydrogen increases resilience to stress in mice. Sci Rep, 2017. 7(1): p. 9625.

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• Zhao, M., et al., Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. J Neuroimmunol, 2016. 294: p. 6-13.

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• Zhang, Y., et al., Effects of hydrogen-rich water on depressive-like behavior in mice. Sci Rep, 2016. 6: p. 23742.

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• Takaenoki, Y., et al., Neonatal exposure to sevoflurane in mice causes deficits in maternal behavior later in adulthood. Anesthesiology, 2014. 120(2): p. 403-15.

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• Yonamine, R., et al., Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice. Anesthesiology, 2013. 118(1): p. 105-13.

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• Zhang, Y., et al., Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis. Neurochem Res, 2016. 41(4): p. 770-8.

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• Zhang, L., et al., Hydrogen has a neuroprotective effect via activation of the Nrf-2/HO-1 pathway in ischemia-reperfusion rat. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016. 9(6): p. 10521-10528.

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• Yang, L., D. Li, and S. Chen, Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy. Open Med (Wars), 2016. 11(1): p. 399-406.

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• Wang, X., et al., The protective effects of hydrogen on HO-1 expression in the brain after focal cerebral ischemia-reperfusion in rats. Turk J Med Sci, 2016. 46(5): p. 1534-1539.

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• Tian, R., et al., Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats. Brain Res, 2016. 1637: p. 1-13.

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• Shao, A., et al., Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome. Mol Neurobiol, 2016. 53(5): p. 3462-3476.

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• Nemeth, J., et al., Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy. J Physiol Pharmacol, 2016. 67(5): p. 677-689.

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• Li, Q., et al., Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210, and NF-kappaB Expression. Neurochem Res, 2016. 41(10): p. 2655-2665.

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• Cui, J., et al., Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats – A possible new hydrogen resource for clinical use. Neuroscience, 2016. 335: p. 232-41.

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• Chen, X., et al., [Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rats with traumatic brain injury]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 2016. 28(5): p. 460-4.

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• Bai, X., et al., Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice. Brain Res, 2016. 1646: p. 410-7.

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• Zhang, Y.G., et al., Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in rats. Experimental and Therapeutic Medicine., 2015. 10(2).

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• Yu, Y., et al., Protective effect of the hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro. Mol Med Rep, 2015. 12(3): p. 3986-92.

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• Wei, R., et al., Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing Oxidative Stress. Cell Physiol Biochem, 2015. 36(2): p. 585-98.

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• Takeuchi, S., et al., Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats. BMC Neurosci, 2015. 16: p. 22.

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• Shao, A., et al., Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome. Mol Neurobiol, 2015.

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• Nakano, T., et al., Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury. J Clin Biochem Nutr, 2015. 57(3): p. 178-82.

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• Lin, C.L., et al., Hydrogen-rich water attenuates amyloid beta-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. Chem Biol Interact, 2015. 240: p. 12-21.

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• Han, L., et al., Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins. Brain Res, 2015.

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• Du, Z., et al., Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock. Int J Clin Exp Med, 2015. 8(5): p. 7620-6.

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• Du, Z., et al., Effects of three hydrogen-rich liquids on hemorrhagic shock in rats. J Surg Res, 2015. 193(1): p. 377-82.

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• Chen, Y., et al., H2Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation, 2015. 38(5): p. 1835-46.

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• Zhang, L., et al., Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3beta in the DRG in rats. Brain Res Bull, 2014. 106C: p. 47-55.

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• Wang, T., et al., Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats. Toxicol Appl Pharmacol, 2014.

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• Mei, K., et al., Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat, 2014. 25(2): p. 182-8.

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• Mano, Y., et al., Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.Free Radic Biol Med, 2014. 69: p. 324-30.

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• Liu, L., et al., Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress, and neuronal apoptosis. Brain Res, 2014. 1589: p. 78-92.

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• Liu, F.T., et al., Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats. CNS Neurosci Ther, 2014.

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• Cui, Y., et al., Hydrogen-rich saline attenuates neuronal ischemia-reperfusion injury by protecting mitochondrial function in rats. J Surg Res, 2014.

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• Zhuang, Z., et al., Nuclear factor-kappaB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. J Neurosci Res, 2013. 91(12): p. 1599-608.

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• Shen, M.H., et al., Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning. CNS Neurosci Ther, 2013. 19(5): p. 361-3.

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• Olah, O., et al., Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs. Neonatology, 2013. 104(2): p. 79-86.

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• Nagatani, K., et al., Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. Med Gas Res, 2013. 3: p. 13.

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• Matsumoto, A., et al., Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice. Sci Rep, 2013. 3: p. 3273.

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• Manaenko, A., et al., Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. Critical Care Medicine, 2013. 41(5): p. 1266-75.

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• Huang, G., et al., The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest. Resuscitation, 2013. 84(5): p. 690-5.

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• Feng, Y., et al., Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Curr Eye Res, 2013. 38(3): p. 396-404.

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• Zhuang, Z., et al., Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BMC Neurosci, 2012. 13: p. 47.

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• Zhou, J., et al., Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. Journal of Surgical Research, 2012. 178(1): p. 390-400.

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• Zhan, Y., et al., Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Critical Care Medicine, 2012. 40(4): p. 1291-6.

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• Wang, W., et al., Hydrogen-rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning. Neurological Research, 2012. 34(10): p. 1007-15.

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• Spulber, S., et al., Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behavior in mice. PLoS One, 2012. 7(7): p. e42078.

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• Ji, X., et al., Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. Journal of Surgical Research, 2012. 178(1): p. e9-16.

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• Ito, M., et al., Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydroxy dopamine-induced Parkinson’s disease in rats. Med Gas Res, 2012. 2(1): p. 15.

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• Hou, Z., et al., Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain Res Bull, 2012. 88(6): p. 560-5.

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• Hong, Y., et al., Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats. J Neurosci Res, 2012. 90(8): p. 1670-80.

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• Yan, H., et al., The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles. BMC Proc, 2011. 5 Suppl 8: p. P69.

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• Wang, C., et al., Hydrogen-rich saline reduces oxidative stress and inflammation by inhibiting JNK and NF-kappaB activation in a rat model of amyloid-beta-induced Alzheimer’s disease. Neuroscience Letters, 2011. 491(2): p. 127-32.

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• Ueda, Y., T. Kojima, and T. Oikawa, Hippocampal gene network analysis suggests that coral calcium hydride may reduce accelerated senescence in mice. Nutrition Research, 2011. 31(11): p. 863-72.

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• Sun, Q., et al., Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Critical Care Medicine, 2011. 39(4): p. 765-9.

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• Shen, L., et al., Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochemical Research, 2011. 36(8): p. 1501-11.

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• Ono, H., et al., Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone, and hydrogen, as compared to Edaravone alone. A non-controlled study. Medical Gas Research, 2011. 1(1): p. 12.

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• Manaenko, A., et al., Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage. Acta Neurochir Suppl, 2011. 111: p. 179-83.

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• Liu, W., et al., Protective effects of hydrogen on fetal brain injury during maternal hypoxia. Acta Neurochir Suppl, 2011. 111: p. 307-11.

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• Kuroki, C., et al.,  Neuroprotective effects of hydrogen gas on the brain in three types of stress models: A P-31-NMR and ESR study. Neuroscience Research, 2011. 71: p. E406-E406.

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• Kobayashi, H., et al., Effects of Hydrogen Gas in a Mouse Cold Induced Brain Injury Model. Journal of Neurotrauma, 2011. 28(5): p. A64-A64.

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• Hugyecz, M., et al., Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Brain Research, 2011. 1404: p. 31-8.

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• Eckermann, J.M., et al., Hydrogen is neuroprotective against surgically induced brain injury. Medical Gas Research, 2011. 1(1): p. 7.

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• Yokoi, I., Neuroprotective effects of hydrogen gas on the brain in three types of stress models: a P-31 NMR and ESR study. Neuroscience Research, 2010. 68: p. E320-E320.

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• Ueda, Y., A. Nakajima, and T. Oikawa, Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride.Neurochemical Research, 2010. 35(10): p. 1510-1515.

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• Li, J., et al., Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress. Brain Res, 2010. 1328: p. 152-161.

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• Ji, X., et al., Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Research, 2010. 1354: p. 196-205.

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• Hong, Y., S. Chen, and J.M. Zhang, [Research advances on hydrogen therapy in nervous system diseases]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010. 39(6): p. 638-43.

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• Gu, Y., et al., Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice. Journal of Clinical Biochemistry and Nutrition, 2010. 46(3): p. 269-276.

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• Domoki, F., et al., Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs. Pediatric Research, 2010. 68(5): p. 387-392.

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• Nagata, K., et al., Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology, 2009. 34(2): p. 501-508.

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• Kuroki, C., et al., Neuroprotective effects of hydrogen gas on the brain in three types of stress models: alpha P-31-NMR study. Neuroscience Research, 2009. 65: p. S124-S124.

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• Fujita, K., et al., Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. PLoS One, 2009. 4(9): p. e7247.

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• Fu, Y., et al., Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neuroscience Letters, 2009. 453: p. 81–85.

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• Sato, Y., et al., Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun, 2008. 375(3): p. 346-350.

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• Kashiwagi, T., et al., Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water. Animal Cell Technology Meets Genomics, 2005. 2: p. 257-260.